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Patients with hepatic or renal impairment: For the prevention or treatment of gout flares, or for FMF, FDA has recommended against the coadministration of Colchicine with protease inhibitors.
Renal dose Adjustments. Familial Mediterranean Fever: Mild (CrCl 50 to 80 mL/min) to moderate (CrCl 30 to 50 mL/min) renal impairment: No dosage adjustment required, but patients should be monitored closely for adverse effects. dosage reduction may be necessary. Severe (CrCl less than 30 mL/min) renal impairment: Dosage should be started at 0.3 mg/day; any increase in dose should be done with adequate monitoring of the patient for adverse effects. In patients with renal impairment who are taking protease inhibitors for the treatment of HIV-1 infection, the FDA has recommended against the coadministration of Colchicine.
Colchicine (Colcrys) is used for treating and preventing pain associated with gouty arthritis. Colchicine (Colcrys) is an anti-gout agent. It works by decreasing inflammation. It may also be used for other conditions as determined by your healthcare professional.
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Colchicine (Colcrys) for Behcet's Disease: Been using Colchicine for over 20 years. No noticeable side effects but do get my bloods checked annually. Only problem was when returned to using it after a two year break. Some diarrhea at first but this stopped after a few weeks once body built up tolerance to drug.
I only take it when I feel an impending attack, and it is amazing. It does cause some diahrrea after 3 days of treatment, but is well worth it, instead of enduring the excruciating pain associated with gout attack. A magic pill indeed.
I do feel this works pretty steady for me.. Not really any stomach issues, just the occassional need to use the toilet often... so I time it and usually stay home when taking this. Im sure to drink lots of water.
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Sally Schneider: I had all kinds of food issues, including health concerns and weight concerns.
Doug Coupland: I want pills called September 10. You take one and your mind feels like the 11th never happened.
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Colchicine Musculoskeletal side effects have been reported the most frequently. These have included myopathy, manifested as weakness, neuropathy, and paralysis.
Call your doctor at once if you have a serious side effect such as muscle pain or weakness, numbness or tingly feeling in your fingers or toes, severe vomiting or diarrhea, easy bruising or bleeding, feeling weak or tired, flu symptoms, blood in your urine, urinating less than usual or not at all, or a pale or gray appearance of your lips, tongue, or hands.
Liver dose Adjustments. Gout Flares: Mild to moderate hepatic impairment: No dose adjustment required, but patients should be monitored closely for adverse effects. Severe hepatic impairment: No dosage adjustment required, but a treatment course should not be repeated more than once every 2 weeks. For patients requiring repeated courses, consideration should be given to alternate therapy.
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And of course a few more testimonials about Colchicine (Colcrys) tabs from various patients:
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Really helps knock down the acute attacks of gout. healthcare professional says as soon as I start getting sick is time to stop taking it.
Colchicine (Colcrys) for Gout, Acute: Reduced initial pain extremely fast. 3 days later had mildly loose stools, slightly crampy stomach.
I have taken Colchicine (Colcrys) off and on during flares, and it seems that it has helped , but it sure makes intestinal problems. I don't want to go out anywhere while taking this medication.
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